Autosomal dominant polycystic kidney disease (ADPKD) is an inherited systemic disorder mainly associated with mutations in the PKD1 gene and characterized by the development of multiple cysts in the kidneys and other organs. There is still a high unmet need for treatment options for patients with ADPKD because Tolvaptan, the only approved treatment, has limited efficacy and non-negligible side effects.

To mimic naturally occurring human PKD1 mutations, a Pkd1 inducible knockout mice strain was established at Novalix. Embark on an exciting journey as we explore the histological characterization of the PDK1flox/flox model using cutting-edge Visiopharm technology. We will unveil captivating insights into the disease’s origins and evolution, revealing the intricate structural changes that define this strain. Join us as we uncover the hidden stories within the tissues, paving the way for potential breakthroughs in understanding and treatment!

Florence Anquetil-Besnard. PhD

Florence Anquetil-Besnard is a Histology Project Manager at NovAliX. After a PharmD and a PhD in Immunology, she began her career in the autoimmune field (rheumatoid arthritis, diabetes) and specialized in histopathology and quantitative image analysis. She is a passionate advocate for digital pathology and loves to solve challenging projects using artificial intelligence (AI) tools. Florence joined the Galapagos team in 2020 to implement the newly formed kidney disease histology area. Her current work within NovAliX also includes oncology projects in diverse organs (brain, pancreas, liver, xenograft tumor…).